Anne Lesage, PhD
office +32 (0)473 900 248


1.       Activation of α7 nicotinic receptors improves phencyclidine-induced deficits in cognitive tasks in rats: implications for therapy of cognitive dysfunction in schizophrenia. McLean SL, Grayson B, Idris NF, Lesage AS, Pemberton DJ, Mackie C, Neill JC. 2010. Eur. Neuropsychopharmacology, Epub ahead of print.

2.       Characterisation of JNJ-1930942, a novel positive allosteric modulator of the a7 nicotinic acetylcholine receptor. Dinklo T, Thuring J-W, Grantham C, Shaban H, Lavreysen H, Peeters L, Meulders G, Stevens K E, Zheng L, Mackie C, Lesage AS 2010. J. Pharm. Exp. Ther. 336: 560-574.

3.       Metabotropic glutamate mGlu1 receptor stimulation and blockade: therapeutic opportunities in psychiatric illness. Lesage ASJ, Steckler T. 2010. Eur. J. Pharmacology 639: 2-16.

4.       Performance of F2 B6x129 hybrid mice in the Morris water maze, latent inhibition and prepulse inhibition paradigms: Comparison with C57Bl/6J and 129sv inbred mice. de Bruin N, Mahieu M, Patel T, Willems R, Lesage A, Megens A. 2006. Behav. Brain Res. 172: 122-34

5.       Desensitization characteristics of the human a7 nAChR/5HT3A chimera receptor. Dinklo, T, Lesage AS, Grantham CG. 2006. J. Mol. Neurosci. 30: 109-110.

6.       A Positron Emission Tomography Radioligand for the in vivo Labeling of Metabotropic Glutamate 1 Receptor: 3-ethyl-2- [11C]methyl-6-quinolinyl)(cis-4-methoxycyclohexyl)methanone. Huang Y, Narendran R, Bischoff F, Guo N, Zhu Z, Bae S-A, Lesage AS, Laruelle M. 2005. J. Med. Chem. 48: 5096-5099.

7.       Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task. Steckler T, Oliveira AFM, Van Dyck C, Van Craenendonck H, Mateus AMA, Langlois X, Lesage ASJ, Prickaerts J. 2005. Behavioural Brain Research 164: 52-60.

8.       Antagonist-induced supersensitivity of mGlu1 receptor signalling in cerebellar granule cells. Lavreysen H, Willemoens T, Leysen JE, Lesage ASJ. 2005. Eur J Neurosci, 21: 1610-1616.

9.       Effect of mGlu1 receptor blockade on anxiety-related behaviour in the rat lick suppression test. Steckler T, Lavreysen H, Oliveira AM, Aerts N, Van Craenendonck H, Prickaerts J, Megens A, Lesage ASJ. 2005. Psychopharmacology 179: 198-206.

10.   Synthesis, structure-activity relationship and receptor pharmacology of a new series of quinoline derivatives acting as selective noncompetitive mGlu1 antagonists. Mabire D, Coupa S, Adelinet C, Poncelet A, Simonnet Y, Venet M, Wouters R, Lesage A, Van Beijsterveldt L, Bischoff F. 2005. J. Med. Chem. 48: 2134 – 2153.

11.   MK-801 alters RGS2 levels and adenylyl cyclase sensitivity in the rat striatum. Taymans J-M, Cruz C, Lesage ASJ, Leysen JE, Langlois X. 2005. NeuroReport 16: 1-4.

12.   JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Lavreysen H, Wouters R, Bischoff F, Nóbrega Pereira S, Langlois X, Blokland S, Somers M, Dillen L, Lesage ASJ. 2004. Neuropharmacology 47: 961-972.

13.   Role of group I metabotropic glutamate receptors mGlu1 and mGlu5 in nociceptive signaling. Review. Lesage ASJ. 2004. Current Neuropharmacology, 2: 363-393.

14.   Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [3H]R214127. Lavreysen H, Nóbrega Pereira S, Leysen JE, Langlois X, Lesage AS. 2004. Neuropharmacology 46: 609-619.

15.   Internalisation of human 5-HT4a and 5-HT4b receptors is splice variant dependent. Pindon A, Van Hecke G, Josson K, Van Gompel P, Lesage AS, Leysen JE, Jurzak M. 2004. Bioscience Reports 24:215-223.

16.   [3H]R214127: A novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Lavreysen H, Janssen C, Bischoff F, Langlois X, Leysen JE, Lesage ASJ. 2003. Mol. Pharmacol. 63: 1082-1093.

17.   Synthesis and biological activities on conformationally restricted cyclopentenyl-glutamate analogues. Ung AT, Schafer K, Lindsay KB, Pyne SG, Amornraksa K, Wouters R, Van der Linden I, Biesmans I, Lesage ASJ, Skelton BW, and White AH. 2002. J. Org. Chem 67: 227-233.

18.   Supersensitivity of human metabotropic glutamate 1a receptor signaling in L929sA cells. Lavreysen H, Le Poul E, Van Gompel P, Dillen Y, Leysen JE, Lesage ASJ. 2002. Mol. Pharm, 61: 1244-1254.

19.   Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii. He W, Cik M, Van Puyvelde L, Van Dun J, Appendino G, Lesage A, Van der Linden I, Leysen JE, Wouters W, Mathenge SG, Mudida FP, De Kimpe N. 2002. Bioorganic & Medicinal Chemistry. 10:3245-3255.

20.   Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Gas- and Gai/o- proteins. Pindon A, Van Hecke G, Van Gompel P, Lesage ASJ, Leysen JE, Jurzak M. 2002. Mol. Pharm, 61: 85-96.

21.   Glutamate receptor subunit expression in primary neuronal and secondary glial cultures. Janssens N, Lesage ASJ. 2001. J. Neurochem, 77: 1457-1474.

22.   Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii. He W, Cik M, Lesage A, Van der Linden I, De Kimpe N, Appendino G, Bracke J, Mathenge SG, Mudida FP, Leysen JE, Van Puyvelde L. 2000. J. Natural Products, 63: 1185-1187.

23.   Mammalian GFRa-4, a divergent member of the GFRa family of coreceptors for Glial Cell line-derived neurotrophic factor family ligands, is a receptor for the neurotrophic factor persephin. Masure S, Cik M, Hoefnagel E, Nosrat CA, Van der Linden I, Scott R, Van Gompel P, Lesage ASJ, Verhasselt P, Ibanez CF, Gordon RD. 2000. J. Biol. Chem. 275: 39427-39434.

24.   Binding of GDNF and neurturin to human GDNF family receptor a1 and 2: Influence of cRET and co-operative interactions. Cik M, Masure S, Lesage ASJ, Van der Linden I, Van Gompel P, Pangalos MN, Gordon RD, Leysen JE. 2000. J. Biol. Chem. 275: 27505-27512.

25.   Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Masure S, Geerts H, Cik M, Hoefnagel E, Van Den Kieboom G, Tuytelaers A, Harris S, Lesage ASJ, Leysen JE, Van der Helm L, Verhasselt P, Yon J, and Gordon BD. 1999. Eur. J. Biochem. 266: 892-902.

26.   Purification of toxic compounds from larvae of the gray fleshfly: the identification of paralysins. Chiou S-J, Kotanen S, Certsiaens A, Daloze D, Pasteels JM, Lesage A, Drijfhout JW, Verhaert P, Dillen L, Claeys M, De Meulemeester H, Nuttin B, De Loof A, Schoofs L. 1998. Biochem. Biophys. Res. Comm. 246: 457-462.

27.   Molecular cloning, expression and tissue distribution of glial cell line-derived neurotrophic factor family receptor a-3 (GFRa-3). Masure S, Cik M, Pangalos MN, Bonaventure P, Verhasselt P, Lesage ASJ, Leysen JE, Gordon RD. 1998. Eur. J. Biochem. 251: 622-630.

28.   Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5HT1B and 5HT1D receptors expressed in various mammalian cell lines. Lesage AS, Wouters R, van Gompel P, Heylen L, Vanhounacker P, Haegeman G, Luyten WHML, Leysen JE, 1998. British J. Pharmacol. 123: 1655-1665.

29.   Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. Uberti D, Rizzini C, Galli P, Pizzi M, Grilli M, Lesage A, Spano P, Memo M, 1997. Synapse 26: 95-103.

30.   Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1Da, human 5-hydroxytryptamine1Db, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. Leysen JE, Gommeren W, Heylen L, Luyten, WHML, Van De Weyer I, Vanhoenacker P, Haegeman G, Schotte A, Van Gompel P, Wouters R, Lesage AS. 1996. Mol. Pharmacol. 50: 1567-1580

31.   Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway. Lesage AS, Peeters L, Leysen JE. 1996. J. Pharm. Exp. Ther. 279: 759-766.

32.   Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Schotte A, Janssen PFM, Gommeren W, Luyten WHML, Van Gompel P, Lesage AS, De Loore KD, Leysen JE, 1996. Psychopharmacology 124: 57-73.

33.   No further evidence for the absence of a growth inhibitory factor in brains of patients with Alzheimer's disease. Van Gool D, Lesage A, Nuydens R, Geerts H, Godderis J Triau, E Dom, R Leysen, J 1995. Alzheimer Research 1: 49-52.

34.   Interaction of new antipsychotics with neurotransmitter receptors in vitro and in vivo: pharmacological to therapeutic significance. Leysen JE, Schotte A, Janssen PMF, Gommeren W, Van Gompel P, Lesage AS, De Backer MD, Luyten WHML, Amlaiky N, Megens AAHP. 1995. Schizophrenia, Alfred Benzon Symposium 38: 344-356.

35.   Cloned human histamine H1- receptors are expressed in mammalian cells; binding properties and signal transduction. De Loore KL, Van Hecke G, Gommeren W, Van Gompel P, Lesage AS, De Backer MD, Luyten WHML, Leysen JE. Neurosci. Res. Commun. 17: 58.

36.   Lubeluzole, a novel neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway. Lesage AS, De Loore KL, Osikowska-Evers B, Peeters L, Leysen JE. 1995. Neurosci. Res. Commun. 17: 58.

37.   Neuroprotective sigma ligands interfere with the glutamate-activated NOS pathway in hippocampal cell culture. Lesage AS, De Loore KL, Peeters L, Leysen JE. 1995. Synapse 20: 156-164.

38.   Various sigma ligands exert long-term protection against glutamate toxicity in primary hippocampal neurons; apparent non-involvement of identified sigma 2 sites. De Loore KL, Lesage AS, Peeters L, Leysen JE, 1994. Neurosci. Res. Commun. 14: 43-51.

39.   Neural regulation of phenylethanolamine N-methyltransferase in vivo: transcriptional and translational changes. Wong DL, Bildstein CL, Sidall B, Lesage A, Yoo YS. 1993. Molecular Brain Res. 18: 107-114.

40.   Glucocorticoid regulation of phenylethanolamine N-methyltransferase in vivo. Wong DL, Lesage A, Sidall B, Funder JW, 1992. FASEB J. 6: 3310-3315.

41.   Adrenergic expression in the rat adrenal gland: multiple developmental regulatory mechanisms. Wong DL, Lesage A, White S, Sidall B, 1992. Brain Res. Dev. Brain Res. 67: 229-236.

Cover by Anne Lesage for Current Neuropharmacology

Role of group I mGlu receptors in nociceptive signaling.

Cover by Anne Lesage for Current Neuropharmacology (2004) Vol. 2: 363-393.